As the lesion progresses, the erythema with central mottling may develop a bleb or blister. A more intense, local pain, often with pruritus occurs after 6-8 hours. The initial bite is often painless and may go unnoticed. The asymmetric shape is due to gravitational spread of venom attached to erythrocytes. The white halo represents ischemic tissue which may later become necrotic. The classic brown recluse spider bite can be identified by its eccentric or asymmetric shape and by the "red, white and blue" sign which results from reactive erythema, vasoconstriction and thrombosis. Bites occur most frequently when the spider is trapped against the body by clothing. The spiders are naturally shy, nocturnal hunters that bite humans only in self defense. The brown recluse prefers dark, dry secluded areas such as woodpiles, attics, storage boxes and piles of clothes. Most envenomations occur March to October when the spiders are active since they hibernate in winter. However, they may be found in any state due to cross-country moving and travel. The spider may survive up to 6 months without food or water.Ä«rown recluse spiders are common to the Southeastern United States, especially in the states of Missouri, Kansas, Arkansas and Tennessee. The average lifespan is 543 days for males and 628 days for females. Crushed spiders may be identified by their three pairs of eyes, unlike some other spider species that have four pairs of eyes. They measure 1 to 5 cm in length from leg to leg. Its long slender legs relative to body size makes it very quick. It may be light tan to dark brown in color and can be distinguished by a darker, inverted violin-shaped marking on its dorsal cephalothorax. Loxosceles reclusa is also known as the brown recluse or fiddle-back spider. A summary based on data compiled from a review of the literature and clinical and laboratory work at Vanderbilt University and the Nashville VA Medical Center The Spider Brown Recluse Spider
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